NRG Blend 120mg Vial

NRG Blend (NAD⁺ / MOTS-c / 5-Amino-1MQ) is a multi-component research formulation combining a metabolic cofactor with two investigational peptides associated with cellular energy regulation and metabolic signaling pathways.

This presentation contains 100 mg NAD⁺, 10 mg MOTS-c, and 10 mg 5-Amino-1MQ in a lyophilized powder format, intended strictly for laboratory research purposes only.

Mechanism of Action (Research Context)

The components of NRG Blend interact with several cellular pathways involved in mitochondrial function and metabolic regulation.

NAD⁺ (Nicotinamide Adenine Dinucleotide)

NAD⁺ is a central redox cofactor involved in cellular metabolism and mitochondrial respiration. It participates in numerous enzymatic reactions including those mediated by:

• Sirtuins (SIRT family)
• PARP enzymes
• Dehydrogenases involved in oxidative phosphorylation

Through these pathways, NAD⁺ is associated with regulation of:

• Cellular energy metabolism
• DNA repair mechanisms
• Mitochondrial function

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)

MOTS-c is a mitochondria-derived peptide encoded within mitochondrial DNA. Research indicates it may influence metabolic homeostasis through:

• AMP-activated protein kinase (AMPK) activation
• Regulation of glucose uptake
• Modulation of mitochondrial stress signaling

MOTS-c has been investigated in models related to metabolic adaptation and exercise physiology.

5-Amino-1MQ (5-Amino-1-Methylquinolinium)

5-Amino-1MQ is a small molecule inhibitor of NNMT (Nicotinamide N-methyltransferase). NNMT is an enzyme involved in methylation pathways that influence NAD⁺ metabolism and cellular energy balance. In research settings, NNMT inhibition has been associated with:

• Alterations in NAD⁺ salvage pathways
• Changes in energy expenditure signaling
• Metabolic pathway modulation

The combined formulation is designed to explore potential synergistic effects on mitochondrial signaling, NAD⁺ metabolism, and metabolic regulation in experimental models.

Molecular Information

NAD⁺

• Class: Pyridine nucleotide coenzyme
• Function: Cellular redox cofactor
• Role: Energy metabolism and enzymatic signaling pathways

MOTS-c

• Class: Mitochondrial-derived peptide
• Length: 16 amino acids
• Target Pathways: AMPK and metabolic signaling

5-Amino-1MQ

• Class: NNMT inhibitor
• Molecular Category: Small molecule metabolic modulator

Presentation

• 100 mg NAD⁺
• 10 mg MOTS-c
• 10 mg 5-Amino-1MQ
• Lyophilized powder in sterile research vial

Storage

• Store lyophilized vial at 2–8 °C
• Protect from light and moisture
• For stability information, refer to laboratory handling guidelines

Research Applications

• Cellular energy metabolism studies
• Mitochondrial signaling research
• NAD⁺ metabolic pathway investigation
• AMPK pathway and metabolic adaptation models
• NNMT inhibition and metabolic regulation studies

FOR RESEARCH USE ONLY